baryawno lab

publications

scp

Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma

Authors:
Olsen TK*, Otte J*, Mei S*, Embaie BT, Kameneva P, Cheng H, Gao T, Zachariadis V, Tsea I, Björklund Å, Kryukov E, Hou Z, Johansson A, Sundström E, Martinsson T, Fransson S, Stenman J, Fard S, Johnsen JI, Kogner P, Adameyko I, Enge M, Kharchenko PV#, Baryawno N#.

*Co-first
#Co-senior

Molecular Cancer
Year: 2024
Volume: 23

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Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature

Authors:
M Shenglin*, Alchahin AM*, Embaie B, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P#, Baryawno N#.

*Co-first
#Co-senior

JCI Insights
Year: 2024
Volume: 9

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Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions

Authors:
M Shenglin#, Alchahin AM#, Tsea I# , Kfoury Y, Hirz T, Jeffries NE, Zhao T, Xu Y, Zhang H, Sarkar H, Wu S, Subtelny AO, Johnsen JI, Zhang Y, Salari K, Wu CL, Randolph MA, Scadden DT, Dahl DM, Shin J, Kharchenko PV, Saylor PJ, Sykes DB, Baryawno N.

#Co-first

Genome Medicine
Year: 2024
Volume: 16

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Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses

Authors:
Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven BM, Subtelny AO, Zlatev DV, Wszolek MW, Salari K, Murray E, Chen F, Macosko EZ, Wu CL, Scadden DT, Dahl DM, Baryawno N#, Saylor SJ#, Kharchenko PV#, Sykes DB#.

#Co-senior

Nature Communications
Year: 2023
Volume: 14
Issue: 663

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Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines

Authors:
Woo SY, Lee H, Park SM, Choi HS, Kim J, Kwon M, Sohn J, Nam JH, Kim HS, Song P, Baryawno N#, Kim YH#, Kim K#, Lee D#.

#Co-senior

Cell Death & Disease
Year: 2022
Volume: 3
Issue: 916

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A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

Authors:
Alchahin AM*, Mei S*, Tsea I, Hirz T, Kfoury Y, Dahl D, Wu CL, Subtelny AO, Wu S, Scadden DT, Shin JH, Saylor PJ#,  Sykes DB#, Kharchenko PV#, Baryawno N#.

*Co-first
#Co-senior

Nature Communications
Year: 2022
Volume:
Issue:

jci

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

Authors:
Olsen TK*, Dyberg C*, Embaie BT, Alchahin A, Milosevic J, Ding J, Otte J, Tümmler C, Myrberg I, Westerhout EM, Koster J, Versteeg R, Ding HF, Kogner P,  Johnsen JI, Sykes DB#, Baryawno N#.

*Co-first
#Co-senior

Journal of Clinical Investigation Insights
Year: 2022
Volume: 7
Issue: 17

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The immune cell atlas of human neuroblastoma

Authors:
Verhoeven BM*, Mei S*, Olsen TK, Gustafsson K, Valind A,  Lindström A, Gisselsson D, Fard SS, Hagerling C#, Kharchenko PV#, Kogner P#, Johnsen JI#, Baryawno N#.

*Co-first
#Co-senior

Cell Reports Medicine
Year: 2022
Volume: 3
Issue: 6

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Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

Authors:
Kfoury N*, Baryawno N* Severe N*, Mei S*, Gustafsson K*, Hirz T*, Brouse T, Scadden EW, Igolkina AA, Kokkaliaris K, Choi BD, Barkas N, Randolph MA, Shin JH, Saylor PJ, Scadden DT, Sykes DB, Kharchenko PV, and as part of the Boston Bone Metastases Consortium.

*Co-first

Cancer Cell
Year: 2021
Volume: 39
Page: 1439-1548

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A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia.

Authors:
Baryawno N*, Przybylski D*, Kowalczyk MS*, Kfoury Y, Severe N, Gustafsson UK, Kokkaliaris KD, Mercier F, Tabaka M, Hofree M, Dionne D, Papazian A, Lee D, Ashenberg O, Subramanian A, Vaishnav ED, Rozenblatt-Rosen O,  Regev A, Scadden DT.

*Co-first

Cell
Year: 2019
Volume: 177
Page: 1915-1932

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Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer.

Authors:
Ubellacker JM, Baryawno N, Severe N, DeCristo MJ, Sceneay J, Hutchinson JN, Haider MT, Rhee CS, Qin Y, Gregory WM, Garrido-Castro AC, Holen I, Brown JE, Coleman RE, Scadden DT, McAllister SS.

Cancer Research
Year: 2018
Volume: 78
Page: 5300-5314

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dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments.

Authors:
Petukhov V, Guo J, Baryawno N, Severe N, Scadden DT, Samsonova MG, Kharchenko PV.

Genome Biology
Year: 2018
Volume: 19
Page: 78

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Introduction to Single-Sell RNA Sequencing.

Authors:
Ohlsen TK, Baryawno N.

Current Protocols
Year: 2018
Volume: 122
Page: e57

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Bone marrow drives central nervous system regeneration after radiation injury.

Authors:
Dietrich J*, Baryawno N*, Nayyar N, Valtis YK, Yang B1, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT.

*Co-first

Journal Of Clinical Investigation
Year: 2017
Volume: 128
Page: 281-293

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Hematopoiesis: Reconciling Historic Controversies about the Niche.

Authors:
Baryawno N, Severe N, Scadden DT.

Cell Stem Cell
Year: 2017
Volume: 20
Page: 590-592

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Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.

Authors:
Hoggatt J, Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV, Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT, Pelus LM.

Cell
Year: 2017
Volume: 172
Page: 191-204

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Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Authors:
Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ.

Science
Year: 2017
Volume: 358
Issue: 6367

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Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.

Authors:
Kalaitzidis D, Lee D, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM, Scadden DT.

Journal of Clinical Investigation
Year: 2017
Volume: 127
Page: 1405-1413

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Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.

Authors:
Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT.

Cell Stem Cell
Year: 2016
Volume: 19
Page: 530-543

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Epigenetic Memory Underlies Cell Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells

Authors:
Yu VWC , Yusuf RZ, OkiT, Wu J, Saez B, Wang X, Cook C, Baryawno N, Ziller MJ, Lee E, Gu H, Meissner A, Lin CP, Kharchenko PV, Scadden DT.

Cell 
Year: 2016
Volume: 167
Pages: 1310-1322

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Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

Authors:
Wickström M, Dyberg C, Milosevic J, Christer E, Calero R, Sveinbjörnsson B, Sandeé E, Darabi A, Siesjö P, Kool M, Kogner P, Baryawno N# & Johnsen J#.

#Co-senior

Nature Communications
Year: 2015
Volume: 25
Article Number: 8904

Baryawno Lab Publications

Frequent detection of human cytomegalovirus in neuroblastoma: A novel therapeutic target?

Authors:
Wolmer-Solberg N*, Baryawno N*, Rahbar A, Fuchs D, Odeberg J, Taher C, Wilhelmi V, Milosevic J, Mohammad AA, Martinsson T, Sveinbjörnsson B, Johnsen JI, Kogner P, Söderberg-Nauclér C.

International Journal of Cancer
Year: 2013
Volume: 133 (10)
Article Number:  2351-61

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Detection of human cytomegalovirus in medulloblastomas reveals a novel therapeutic target

Authors: 
Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, Odeberg J, Darabi A, Khan Z, Sveinbjörnsson B, Fuskevåg OM, Segerström L, Nordenskjöld M, Siesjö P, Kogner P, Johnsen JI and Söderberg-Nauclér C.

Journal of Clinical Investigation
Year: 2011
Volume: 121
Article Number: 4043-55

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Small molecule inhibitors of PI3K/AKT signaling inhibit Wnt/β-catenin pathway crosstalk and suppress medulloblastoma growth.

Authors:
Baryawno N, Sveinbjörnsson B, Eksborg S, Chen CS, Kogner P, Johnsen JI.

Cancer Research
Year: 2011
Volume: 70
Pages: 266-76

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Tumour growth promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets

Authors:
Baryawno N, Sveinbjörnsson B, Eksborg S, Orrego A, Segerström L, Öqvist CO, Holm S, Gustavsson B, Kågedal B, Kogner P, Johnsen JI.

Neuro-Oncology
Year: 2008
Volume: 10
Pages: 661-74